Inflammatory Bowel Disease Models

Wild Mouse 750
Wild Mouse 750
Human Xenograft Models
Cell Derived Xenograft Models
자가면역질환 모델
Rheumatoid Arthritis ModelsPsoriasis ModelsInflammatory Bowel Disease ModelsAtopic Dermatitis Models Asthma Models
대사성 질환 마우스 모델
Obesity ModelsDiabetes ModelsNon-alcoholic Steatohepatitis (NASH) ModelsHyperlipidemia ModelsOsteoporosis ModelsHyperuricemia Models
Humanized Immune System Models
huPBMC-NCGhuHSC-NCG-XhuHSC-NCG-hIL15huHSC-NCG
Organs or Tissue Humanized Mouse Models
Genetically Humanized Mouse Models
Wild Mouse 765
Wild Mouse 765
희귀 질환 마우스 모델
자가면역질환 모델Hemophilia A Models
신경퇴행성 질환 마우스 모델
Alzheimer’s Disease (AD) ModelsParkinson’s Disease (PD) ModelsHuntington's Disease (HD) ModelsAmyotrophic Lateral Sclerosis (ALS) ModelsTransthyretin Amyloidosis (ATTR) Models
면역-종양 마우스 모델
Human Xenograft ModelsHumanized Immune Checkpoint ModelsHumanized Immune System ModelsSpontaneous Tumor Models

Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease. It mainly includes Crohn disease (CD) and ulcerative colitis (UC).


Validation data

  1. Phenotypic data of TNBS-induced CD models

图片9.png

Disease activity index (DAI) of TNBS-treated  group increased significantly (upper left panel), and the survival rate was about 70%7 days after TNBS induction (upper right panel).

The colonic mucosa of TNBS-treated mice appeared hyperemic and edematous with local ulcer (lower left panel). The intestinal wall of the TNBS-treated group was thickened and invaded the muscle layer. Newly formed vessels were associated with inflammatory cell infiltration (lower right panel).

Notice: 2,4,6-trinitrobenzene sulfonic acid (TNBS) and ethanol mixture is intrarectally administered to the mice. DAI=(Weight loss score + stool trait score + stool occult blood score)/ 3

 

  2. Phenotypic data of DSS-induced UC models

图片10.png

The body weight of mice decreased significantly after Dextran Sulfate Sodium (DSS) induction. Intestinal histological examination showed focal, transmural inflammation and ulceration.