Psoriasis Models

Wild Mouse 750
Wild Mouse 750
Human Xenograft Models
Cell Derived Xenograft Models
자가면역질환 모델
Rheumatoid Arthritis ModelsPsoriasis ModelsInflammatory Bowel Disease ModelsAtopic Dermatitis Models Asthma Models
대사성 질환 마우스 모델
Obesity ModelsDiabetes ModelsMASH ModelsHyperlipidemia ModelsOsteoporosis ModelsHyperuricemia Models
Humanized Immune System Models
huPBMC-NCGhuHSC-NCG-XhuHSC-NCG-hIL15huHSC-NCG
Organs or Tissue Humanized Mouse Models
Genetically Humanized Mouse Models
Wild Mouse 765
Wild Mouse 765
희귀 질환 마우스 모델
자가면역질환 모델Hemophilia A Models
신경퇴행성 질환 마우스 모델
Alzheimer’s Disease (AD) ModelsParkinson’s Disease (PD) ModelsHuntington's Disease (HD) ModelsAmyotrophic Lateral Sclerosis (ALS) ModelsTransthyretin Amyloidosis (ATTR) Models
면역-종양 마우스 모델
Human Xenograft ModelsHumanized Immune Checkpoint ModelsHumanized Immune System ModelsSpontaneous Tumor Models

Psoriasis is an immune-mediated inflammatory skin disease, and its pathogenesis is related to inflammatory cell infiltration and inflammatory factors. Imiquimod (IMQ)-induced mouse model is the most commonly used psoriasis model.


Modeling strategy

1.png

Validation data

  1. Phenotypic data of IMQ-induced psoriasis mouse models (BALB/c)

Skin damage, inflammation, thickening and peeling occurred on the back of IMQ-induced mice, and the disease scores of the IMQ groups were  significantly higher than that of the control group. Tissue sections show epidermal thickening and neutrophil infiltration in IMQ-induced mice.

 

  2. Efficacy Results of Dexamethasone and Secukinumab in IMQ-induced Psoriasis Mice (BALB/c-hIL17A)

图片1.png

The disease scores of mice treated with Dexamethasone and Secukinumab decreased. The results demonstrate that IMQ-induced model can be used for preclinical studies and efficacy evaluation of psoriasis medications.