CDX Cell Lines
세포주 유래 이종이식 모델(CDX 모델)은 사람 유래 종양세포를 마우스 피하에 이식한 in vivo 모델로, 효능 평가나 종양 연구에 활용할 수 있습니다. 항암제 비임상 연구에 가장 자주 활용되는 in vivo 모델 중 하나입니다.
젬파마텍은 췌장암, 유방암, 대장암, 폐암, 림프종 등의 방대한 CDX 세포주 컬렉션을 보유하고 있어, 이를 필요로 하는 다양한 약력학적 연구 및 유효성 평가에 대응할 수 있습니다. 이외에도 32종의 CDX 세포주를 Luciferase를 발현하도록 변형하여, 생체발광을 통해 종양 용적을 비침습적으로 분석할 수 있습니다.
| Cancer Type | Unmodified Cell Line | Luciferase-Tagged Cell Line |
| Ademocarcimoma | Calu-3, NCI-H1666, NCI-H441,NCI-H1650 | |
| Acute Myeloid Leukemia | MOLM13, OCIAML3 | |
| Anaplastic Carcinoma | Calu-6 | |
| Barett Adenocarcinoma | OE33 | |
| Bladder Cancer | UM-UC-3, HT1376, RT4, T24, RT112/84 | |
| Brain Cancer | U251, U-87 MG | |
| Breast Cancer | BT-20, BT-474, BT-549, HCC1937, HCC1954, HCC1569, Hs 578T, JIMT-1, MCF7, MDA-MB-175VII, MDA-MB-231, MDA-MB-436, MDA-MB-453, MDA-MB-468, SK-BR-3, HCC70, T47D | MDA-MB-468-Luc, MDA-MB-231-Luc, MCF-Luc |
| Chondrosarcoma | SW1353 | |
| Clear Cell Carcinoma | Es-2 | |
| Colorectal Cancer | Colo205, HCT-116, HT29, HT-55, LoVo, LS174T, RKO, SW48 | |
| Colorectal Cancer; Dukes' Type C | Ls1034 | |
| Colorectal Cancer; Dukes' Type C, Grade III | SW948 | |
| Colorectal Cancer; Dukes' Type B | SW480 | |
| Colon Cancer | HT-29-Luc, HCT116-Luc, RKO-Luc | |
| Colon Adenocarcinoma | COLO-320 | |
| Duodenal Cancer | HuTu 80 | |
| Endometrial Carcinoma | HEC-1-A | |
| Esophagus | KYSE-150 | |
| Gastric Cancer | Hs 746T, MKN45, NCI-N87, SGC-7901, SNU-16, KATOIII, NUGC4 | |
| Glioblastoma | U251-Luc, U87 MG-Luc | |
| Leukemia | HL-60, Jurkat, K562, MOLT-4, MV-4-11, Nalm-6, SUP-B15, THP-1, CCRF-CEM, Hut78, TF1, Hs 505.T | Nalm6-Luc, K562-Luc, MOLM 13-Luc, HL60-Luc, MV-4-11-Luc, Jurkat-Luc |
| Liver Cancer | HepG2, Huh7 | Huh7-Luc, HepG2-Luc |
| Lung Cancer | A549-Luc, NCI-H82, NCI-H2171 | |
| Lymphoma | U937, NK92, Jeko-1, Daudi, Ramos, JVM-2, KAPPAS 299, Raj, SU-DHL-10, SU-DHL-16, U-2932, L-540 | Raji-Luc, U-937-Luc, MM.1S-Luc, Jeko-Luc, Thp-1-Luc, Daudi-Luc, Ramos |
| Melanoma | A375, COLO829, SK-MEL-28, SK-MEL-5 | A375-Luc |
| Multiple Myeloma | NCI-H929, MM.1R, MOLP-8, RPMI-8226, MM.1S | RPMI8226-Luc |
| Neuroblastoma | IMR-32, SK-N-BE(2) | |
| NSCLC | A549, HCC-827, NCI-H1703, NCI-H1755, NCI-H1975, NCI-H2122, NCI-H358, NCI-H460, NCI-H1299, NCI-H647 | |
| Osteosarcoma | MG63 | |
| Ovarian Cancer | OVCAR-3, SK-OV-3, TOV-112D | SKOV3-Luc, OVCAR-Luc |
| Pancreatic Cancer | AsPC-1, BxPC-3, CAPAN-1, CFPAC-1, HPAC, MIA PaCa-2, PANC-1, SW1990 | PANC-Luc |
| Plasmacytoma | U-266 | |
| Prostate Cancer | 22RV1, LNCaP, PC-3, LNCaP C4-2B | |
| Pulmonary Mucoepidermoid Carcinoma | NCI-H226, NCI-H292, NCI-H727, NCI-H69 | |
| Renal Carcinoma | ACHN, 786-O | |
| Sarcoma | HT1080, SJSA-1, U-2 OS | |
| SCLC | DMS-53, NCI-2171, NCI-H446, NCI-H526, NCI-H82, SHP-77 | |
| Skin Cancer | A431 | |
| Submandibular Adenosquamous Carcinoma | A253 | |
| Squamous Cell Carcinoma | FaDu | |
| Teratocarcinoma | PA-1 | |
| Tongue Squamous Cell Carcinoma | Cal 27 | |
| Uterine Cancer | HEC-1-A-Luc |